发明申请
US20100331320A1 CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
审中-公开
11BETA - 羟基脱氢酶脱氢酶的循环抑制剂1
- 专利标题： CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 11BETA - 羟基脱氢酶脱氢酶的循环抑制剂1
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申请号： US12771499申请日： 2010-04-30
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公开(公告)号： US20100331320A1公开(公告)日： 2010-12-30
- 发明人: Martin Renz , Martin Schuehle , Zhenrong Xu
- 申请人： Martin Renz , Martin Schuehle , Zhenrong Xu
- 专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 当前专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 优先权： USPCT/US2009/002653 20090430; USPCT/US2009/004261 20090723
- 主分类号： A61K31/5355
- IPC分类号： A61K31/5355 ; C07D413/10 ; A61P3/10
摘要：
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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