发明申请
US20110003779A1 15, 16-METHYLENE-17-(1'-PROPENYL)-17,3'-OXIDOESTRA-4-EN-3-ONE DERIVATIVE , USE THEREOF, AND MEDICAMENT CONTAINING SAID DERIVATIVE
失效
15,16-甲基-17-(1'-丙烯)-17,3'-氧化四环素-4-烯-3-酮衍生物,其用途及含有衍生物的药物
- 专利标题: 15, 16-METHYLENE-17-(1'-PROPENYL)-17,3'-OXIDOESTRA-4-EN-3-ONE DERIVATIVE , USE THEREOF, AND MEDICAMENT CONTAINING SAID DERIVATIVE
- 专利标题(中): 15,16-甲基-17-(1'-丙烯)-17,3'-氧化四环素-4-烯-3-酮衍生物,其用途及含有衍生物的药物
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申请号: US12810857申请日: 2008-12-23
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公开(公告)号: US20110003779A1公开(公告)日: 2011-01-06
- 发明人: Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hubner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 申请人: Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hubner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 优先权: DE102007063496.1 20071229
- 国际申请: PCT/EP2008/011164 WO 20081223
- 主分类号: A61K31/58
- IPC分类号: A61K31/58 ; C07J21/00 ; A61P15/18 ; A61P15/12 ; A61P15/00
摘要:
The invention relates to 15,16-methylene-17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the Z, R4, R6a, R6b, R7 and R18 have the meanings stated in claim 1, and solvates, hydrates and salts thereof, including all crystal modifications and all stereoisomers of these compounds. The invention also relates to the use of these derivatives for the production of a drug for oral contraception and for the treatment of pre-, peri- and postmenopausal problems and drugs which contain such derivatives, in particular use in the aforesaid indications. The derivatives according to the invention have a progestational and in preferable cases also an antimineralcorticoid and neutral to slight androgenic activity.
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