发明申请
US20110004953A1 Method Of Identifying A Compound For Preventing And/Or Treating An Autoimmune Disease
失效
鉴定化合物用于预防和/或治疗自身免疫性疾病的方法
- 专利标题： Method Of Identifying A Compound For Preventing And/Or Treating An Autoimmune Disease
- 专利标题（中）： 鉴定化合物用于预防和/或治疗自身免疫性疾病的方法
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申请号： US12749593申请日： 2010-03-30
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公开(公告)号： US20110004953A1公开(公告)日： 2011-01-06
- 发明人: Norihiko Watanabe , Yoshihiro Oya
- 申请人： Norihiko Watanabe , Yoshihiro Oya
- 申请人地址： JP Chiba-shi
- 专利权人： NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
- 当前专利权人： NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
- 当前专利权人地址： JP Chiba-shi
- 主分类号： A01K67/00
- IPC分类号： A01K67/00 ; C12Q1/02
摘要：
A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA−/−) NKT cell from a non-human animal, contacting the (BTLA−/−) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA−/−) NKT cell to the antigen, comparing the response of the (BTLA−/−) NKT cell to the antigen with a response of a (BTLA−/−) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA−/−) NKT cell in the presence of an antigen compared to a response of a (BTLA−/−) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.
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