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16 条记录 (耗时 0.036 秒)

    Engine valve train
    4.
    发明授权
    Engine valve train 失效
    发动机气门机构

    公开(公告)号：US06830018B2

    公开(公告)日：2004-12-14

    申请号：US10617780

    申请日：2003-07-14

    申请人： Mitsuru Sugimoto ,  Atsushi Umemoto ,  Norihiko Watanabe

    发明人： Mitsuru Sugimoto ,  Atsushi Umemoto ,  Norihiko Watanabe

    IPC分类号： F01L904

    CPC分类号： F01L9/04 ,  F01L1/18 ,  F01L1/267 ,  F01L2013/0089

    摘要： An engine valve train having a camshaft supported on a camshaft holder and driving inlet valves to open and close via inlet rocker arms; an electromagnetic actuator mechanism including an armature; a holding rod connected to the armature and pressing against a stem end of the inlet valve so as to hold the inlet valve in an open state; and, a hydraulic damper mechanism absorbing an impact which is generated by the inlet valve when the inlet valve is released from being held by the electromagnetic actuator mechanism so as to be restored to a closed state and is then seated, wherein the hydraulic damper mechanism is supported on the camshaft holder.

    摘要翻译： 一种发动机气门机构，其具有支撑在凸轮轴保持器上的凸轮轴，并且驱动入口阀通过入口摇臂打开和关闭; 包括电枢的电磁致动器机构; 连接到所述电枢并且抵靠所述入口阀的杆端的保持杆，以将所述入口阀保持在打开状态; 以及液压阻尼器机构，其吸收当所述入口阀被所述电磁致动器机构解除时由所述入口阀产生的冲击，从而被恢复到关闭状态并且然后就座，其中所述液压阻尼器机构为 支撑在凸轮轴支架上。

    Method Of Identifying A Compound For Preventing And/Or Treating An Autoimmune Disease
    7.
    发明申请
    Method Of Identifying A Compound For Preventing And/Or Treating An Autoimmune Disease 失效
    鉴定化合物用于预防和/或治疗自身免疫性疾病的方法

    公开(公告)号：US20110004953A1

    公开(公告)日：2011-01-06

    申请号：US12749593

    申请日：2010-03-30

    申请人： Norihiko Watanabe ,  Yoshihiro Oya

    发明人： Norihiko Watanabe ,  Yoshihiro Oya

    IPC分类号： A01K67/00 ,  C12Q1/02

    CPC分类号： G01N33/505 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0387 ,  C07K14/70503 ,  C07K14/70578 ,  G01N33/5023 ,  G01N33/564 ,  G01N33/576

    摘要： A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA−/−) NKT cell from a non-human animal, contacting the (BTLA−/−) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA−/−) NKT cell to the antigen, comparing the response of the (BTLA−/−) NKT cell to the antigen with a response of a (BTLA−/−) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA−/−) NKT cell in the presence of an antigen compared to a response of a (BTLA−/−) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.

    摘要翻译： 描述了鉴定用于预防和/或治疗自身免疫疾病的化合物的方法，其包括从非人动物获得（BTLA - / - ）NKT细胞，使（BTLA - / - ）NKT细胞离体与 测试化合物，在抗原存在下，测量（BTLA - / - ）NKT细胞对抗原的反应，比较（BTLA - / - ）NKT细胞与抗原的反应与（BTLA - - / - ）NKT细胞，并且选择在抗原存在下降低（BTLA - / - ）NKT细胞的反应的化合物与（BTLA - / - ）NKT细胞在 对照试验。 还描述了鉴定用于预防和/或治疗自身免疫性疾病的化合物的其它方法。