发明申请
- 专利标题： NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF
- 专利标题（中）： 新型抗IL 13抗体及其用途
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申请号： US12240604申请日： 2008-09-29
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公开(公告)号： US20110014199A1公开(公告)日： 2011-01-20
- 发明人: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- 申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C07H21/04 ; A61P11/00 ; A61P37/08 ; C12N5/16 ; C12N15/63 ; C12N5/10
摘要：
The present invention relates to anti IL13 antibodies that hind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
公开/授权文献
- US08088618B2 Anti-IL 13 antibodies and uses thereof 公开/授权日：2012-01-03
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