发明申请
US20110015250A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE
审中-公开
用于抑制Eg5基因表达的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE
- 专利标题（中）： 用于抑制Eg5基因表达的组合物和方法
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申请号： US12754110申请日： 2010-04-05
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公开(公告)号： US20110015250A1公开(公告)日： 2011-01-20
- 发明人: David Bumcrot , Pamela Tan , Hans-Peter Vornlocher , Anke Geick
- 申请人： David Bumcrot , Pamela Tan , Hans-Peter Vornlocher , Anke Geick
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C07H21/02 ; A61P35/00 ; C12N15/63 ; C12N5/071
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.
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