发明申请
US20110021472A1 17-HYDROXY-19-NOR-21-CARBOXYLIC ACID-STEROID Y-LACTONE DERIVATIVE, USE THEREOF, AND MEDICAMENT CONTAINING THE DERIVATIVE
有权
17-羟基-19-异-21-羧酸 - 甾体Y-LACTONE衍生物，其用途和含有衍生物的药物
- 专利标题： 17-HYDROXY-19-NOR-21-CARBOXYLIC ACID-STEROID Y-LACTONE DERIVATIVE, USE THEREOF, AND MEDICAMENT CONTAINING THE DERIVATIVE
- 专利标题（中）： 17-羟基-19-异-21-羧酸 - 甾体Y-LACTONE衍生物，其用途和含有衍生物的药物
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申请号： US12810991申请日： 2008-12-23
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公开(公告)号： US20110021472A1公开(公告)日： 2011-01-27
- 发明人: Ulrich Klar , Jooachim Kuhnke , Rolf Bohlmann , Jan Huebner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 申请人： Ulrich Klar , Jooachim Kuhnke , Rolf Bohlmann , Jan Huebner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans Peter Muhn , Katja Prelle
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 优先权： DE102007063503.8 20071229
- 国际申请： PCT/EP2008/011159 WO 20081223
- 主分类号： A61K31/585
- IPC分类号： A61K31/585 ; C07J21/00 ; A61P15/18
摘要：
The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula I, where R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.
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