发明申请
- 专利标题： Cyclic Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1
- 专利标题（中）： 11β-羟基类固醇脱氢酶的循环抑制剂1
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申请号： US12741522申请日： 2009-04-30
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公开(公告)号： US20110021512A1公开(公告)日： 2011-01-27
- 发明人: David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Suresh B. Singh , Salvacion Cacatian , Wei Zhao
- 申请人： David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Suresh B. Singh , Salvacion Cacatian , Wei Zhao
- 专利权人： VITAE PHARMACEUTICALS, INC.
- 当前专利权人： VITAE PHARMACEUTICALS, INC.
- 优先权： USPCT/US2008/009017 20080725
- 国际申请： PCT/US09/02653 WO 20090430
- 主分类号： A61K31/5355
- IPC分类号： A61K31/5355 ; C07D413/10 ; C07D413/14 ; A61P3/10
摘要：
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
公开/授权文献
- US08138178B2 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 公开/授权日：2012-03-20
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