发明申请
US20110028696A1 MONOCLONAL ANTIBODIES AGAINST PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LACKING IN FUCOSYL RESIDUES
有权
单克隆抗体抗前列腺特异性抗原（PSMA）在FUCOSYL残留中的缺失
- 专利标题： MONOCLONAL ANTIBODIES AGAINST PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LACKING IN FUCOSYL RESIDUES
- 专利标题（中）： 单克隆抗体抗前列腺特异性抗原（PSMA）在FUCOSYL残留中的缺失
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申请号： US12903853申请日： 2010-10-13
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公开(公告)号： US20110028696A1公开(公告)日： 2011-02-03
- 发明人: Josephine M. CARDARELLI , David B. PASSMORE , Jenny ALBANESE , Lei ZHU
- 申请人： Josephine M. CARDARELLI , David B. PASSMORE , Jenny ALBANESE , Lei ZHU
- 申请人地址： US NJ Princeton
- 专利权人： MEDAREX, INC.
- 当前专利权人： MEDAREX, INC.
- 当前专利权人地址： US NJ Princeton
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K19/00
摘要：
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.
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