公开(公告)号：US08207303B2

公开(公告)日：2012-06-26

申请号：US11918178

申请日：2006-02-17

申请人： Josephine M. Cardarelli ,  Amelia Nancy Black

发明人： Josephine M. Cardarelli ,  Amelia Nancy Black

IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2878 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺乏岩藻糖基残基的抗-CD30抗体。 本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性，包括裂解不被所述抗体的岩藻糖基化形式裂解的CD30表达细胞系的能力。 本发明还提供表达缺乏岩藻糖基残基的抗-CD30抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺陷的。 还提供了使用抗体抑制CD30 +细胞如肿瘤细胞生长的方法。

公开(公告)号：US20110028696A1

公开(公告)日：2011-02-03

申请号：US12903853

申请日：2010-10-13

申请人： Josephine M. CARDARELLI ,  David B. PASSMORE ,  Jenny ALBANESE ,  Lei ZHU

发明人： Josephine M. CARDARELLI ,  David B. PASSMORE ,  Jenny ALBANESE ,  Lei ZHU

IPC分类号： C07K16/28 ,  C07K19/00

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US20110020329A1

公开(公告)日：2011-01-27

申请号：US12745337

申请日：2008-11-26

申请人： David J. King ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

发明人： David J. King ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/09 ,  A61P35/00

CPC分类号： A61K47/6869 ,  A61K47/6809

摘要： Anti-RG-1 antibodies, antibody fragments, or antibody mimetics conjugated to partner molecules, such as drugs, radioisotopes, and cytotoxins, wherein the partner molecule exerts its effect regardless of whether the RG-1 bound conjugate is internalized within a targeted cell, are useful for treating cancers.

摘要翻译： 抗RG-1抗体，抗体片段或偶联于配偶体分子（例如药物，放射性同位素和细胞毒素）的抗体模拟物，其中配偶体分子发挥其作用，而不管RG-1结合的缀合物是否内化在靶细胞内， 可用于治疗癌症。

公开(公告)号：US20100158902A1

公开(公告)日：2010-06-24

申请号：US12377015

申请日：2007-08-10

申请人： Sarah L. Pogue ,  Alan J. Korman ,  Josephine M. Cardarelli ,  Mohan Srinivasan ,  Bingliang Chen ,  Alasdir F. Bell

发明人： Sarah L. Pogue ,  Alan J. Korman ,  Josephine M. Cardarelli ,  Mohan Srinivasan ,  Bingliang Chen ,  Alasdir F. Bell

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/00 ,  C12N15/74 ,  C12N5/10 ,  C12P21/00 ,  A61P37/06 ,  A61P35/00

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.

摘要翻译： 本公开提供以高亲和力特异性结合SDF-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码SDF-1抗体的核酸分子，表达载体，宿主细胞和用于表达SDF-1抗体的方法。 还提供了免疫偶联物，双特异性分子和包含SDF-1抗体的药物组合物。 公开了用于检测SDF-1的方法，以及用于治疗各种B细胞恶性肿瘤（包括乳腺癌，多发性骨髓瘤和非霍奇金淋巴瘤）和自身免疫性疾病的方法。

公开(公告)号：US07741449B2

公开(公告)日：2010-06-22

申请号：US11009410

申请日：2004-12-10

申请人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

发明人： Alison Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David King ,  David Passmore

IPC分类号： C07K16/00 ,  C07K16/24 ,  A61K39/395

CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

公开(公告)号：US07619070B2

公开(公告)日：2009-11-17

申请号：US10831459

申请日：2004-04-23

申请人： Josephine M. Cardarelli ,  Tseng-Hui Timothy Chen ,  David J. King ,  Christopher R. Bebbington ,  Sarah Lee Pogue ,  Francis J. Carr ,  Stephen Williams

发明人： Josephine M. Cardarelli ,  Tseng-Hui Timothy Chen ,  David J. King ,  Christopher R. Bebbington ,  Sarah Lee Pogue ,  Francis J. Carr ,  Stephen Williams

IPC分类号： C12P21/08

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。

公开(公告)号：US20090162372A1

公开(公告)日：2009-06-25

申请号：US12271623

申请日：2008-11-14

申请人： David J. KING ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

发明人： David J. KING ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00

CPC分类号： C07K16/18 ,  A61K47/6803 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/92

摘要： The present invention provides anti-ED-B antibodies, antibody fragments, and antibody mimetics and such antibodies conjugated to a partner molecule, wherein the antibody or the antibody-partner molecule conjugate provides a therapeutic effect regardless of whether the ED-B-antibody or ED-B-conjugate complex is internalized within a targeted cell.

摘要翻译： 本发明提供抗ED-B抗体，抗体片段和抗体模拟物以及与配偶体分子缀合的抗体，其中抗体或抗体 - 配偶体分子缀合物提供治疗效果，而不管ED-B-抗体或 ED-B-缀合物复合体内化在靶细胞内。

公开(公告)号：US20090060908A1

公开(公告)日：2009-03-05

申请号：US11918191

申请日：2006-02-17

申请人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

发明人： Josephine M. Cardarelli ,  David B. Passmore ,  Jenny Albanese ,  Lei Zhu

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P31/00 ,  C12N5/06

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

摘要翻译： 本发明涉及缺少岩藻糖基残基的抗PSMA抗体。 与抗体的岩藻糖基化形式相比，本发明的抗体表现出增加的抗体依赖性细胞毒性（ADCC）活性。 本发明还提供表达缺乏岩藻糖基残基的抗PSMA抗体的宿主细胞，其中宿主细胞对于岩藻糖基转移酶是缺乏的。 还提供了使用抗体抑制PSMA +细胞如肿瘤细胞生长的方法。

公开(公告)号：US20090028872A1

公开(公告)日：2009-01-29

申请号：US12065436

申请日：2006-09-26

申请人： Jonathan Alexander Terret ,  Li-Sheng Lu ,  David John King ,  Josephine M. Cardarelli ,  Chin Pan ,  Haichun Huang ,  Marco A. Coccia

发明人： Jonathan Alexander Terret ,  Li-Sheng Lu ,  David John King ,  Josephine M. Cardarelli ,  Chin Pan ,  Haichun Huang ,  Marco A. Coccia

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P31/00 ,  A61P37/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/466

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

摘要翻译： 本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。

公开(公告)号：US08496931B2

公开(公告)日：2013-07-30

申请号：US12377015

申请日：2007-08-10

申请人： Sarah L. Pogue ,  Alan J. Korman ,  Josephine M. Cardarelli ,  Mohan Srinivasan ,  Bingliang Chen ,  Alasdair F. Bell

发明人： Sarah L. Pogue ,  Alan J. Korman ,  Josephine M. Cardarelli ,  Mohan Srinivasan ,  Bingliang Chen ,  Alasdair F. Bell

IPC分类号： A61K39/395

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.

摘要翻译： 本公开提供以高亲和力特异性结合SDF-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码SDF-1抗体的核酸分子，表达载体，宿主细胞和用于表达SDF-1抗体的方法。 还提供了免疫偶联物，双特异性分子和包含SDF-1抗体的药物组合物。 公开了用于检测SDF-1的方法，以及用于治疗各种B细胞恶性肿瘤（包括乳腺癌，多发性骨髓瘤和非霍奇金淋巴瘤）和自身免疫性疾病的方法。