发明申请
- 专利标题： HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS
- 专利标题（中）： 杂环化合物及其作为ERK抑制剂的用途
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申请号： US12601476申请日： 2008-06-17
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公开(公告)号： US20110038876A1公开(公告)日： 2011-02-17
- 发明人: Robert Sun , Alan B. Cooper , Yongqi Deng , Tong Wang , Yang Nan , Hugh Y. Zhu , Sobhana Babu Boga , Xiaolei Gao , Joseph M. Kelly , Sunil Paliwal , Hon-Chung Tsui , Ronald J. Doll , Neng-Yang Shih
- 申请人： Robert Sun , Alan B. Cooper , Yongqi Deng , Tong Wang , Yang Nan , Hugh Y. Zhu , Sobhana Babu Boga , Xiaolei Gao , Joseph M. Kelly , Sunil Paliwal , Hon-Chung Tsui , Ronald J. Doll , Neng-Yang Shih
- 国际申请： PCT/US08/07509 WO 20080617
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/04 ; C07D487/08 ; A61K31/496 ; A61K39/395 ; A61P35/00 ; A61P35/02
摘要：
Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
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