An object of the invention is to provide a tire tube which has excellent air impermeability and such excellent durability that the occurrence of cracks in the tube main body is prevented in a contact surface between the tube main body and an inner circumferential surface of the tire. The tire tube of the invention includes a tube main body having a multilayer structure in which at least one rubber layer and at least one thermoplastic resin layer made of a thermoplastic resin or a thermoplastic elastomer composition obtained by blending an elastomer in a thermoplastic resin are laminated together. In at least a region where the tube main body is in contact with the inner circumferential surface of the tire tread part, the rubber layer is placed as the outermost layer of the multilayer structure, and the thermoplastic resin layer is placed inside the outermost layer.