发明申请
- 专利标题： METHOD FOR PREPARATION OF PLATELET FROM iPS CELL
- 专利标题（中）： 从iPS细胞制备板的方法
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申请号： US12935380申请日： 2009-04-01
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公开(公告)号： US20110053267A1公开(公告)日： 2011-03-03
- 发明人: Hiromitsu Nakauchi , Koji Eto , Hidekazu Nishiki-I , Naoya Takayama , Shinya Yamanaka , Kazutoshi Takahashi
- 申请人： Hiromitsu Nakauchi , Koji Eto , Hidekazu Nishiki-I , Naoya Takayama , Shinya Yamanaka , Kazutoshi Takahashi
- 申请人地址： JP Tokyo
- 专利权人： THE UNIVERSITY OF TOKYO
- 当前专利权人： THE UNIVERSITY OF TOKYO
- 当前专利权人地址： JP Tokyo
- 优先权： JP2008-094584 20080401
- 国际申请： PCT/JP2009/001542 WO 20090401
- 主分类号： C12N5/078
- IPC分类号： C12N5/078 ; C12N5/0789
摘要：
It is an object of the present invention to provide a method for efficiently preparing blood cells, such as mature megakaryocytes and platelets, from iPS cells in an in vitro culture system.The present invention provides a sac-like structure enclosing hematopoietic progenitor cells, which is obtained by inoculating iPS cells onto feeder cells and then culturing the iPS cells under conditions suitable for inducing the differentiation of hematopoietic progenitor cells. Moreover, the present invention also provides a method for producing various types of blood cells, which comprises culturing hematopoietic progenitor cells enclosed in the sac-like structure under conditions suitable for inducing the differentiation of blood cells. Furthermore, the present invention also provides a method for producing various types of blood cells, particularly megakaryocytes and platelets, without involving the sac-like structure.
公开/授权文献
- US08546141B2 Method for preparation of platelet from iPS cell 公开/授权日：2013-10-01