发明申请
- 专利标题： Protein Kinase Inhibitors and Methods for Using Thereof
- 专利标题（中）： 蛋白激酶抑制剂及其使用方法
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申请号： US12665894申请日： 2008-06-18
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公开(公告)号： US20110053932A1公开(公告)日： 2011-03-03
- 发明人: Taebo Sim , Truc Ngoc Nguyen , Baogen Wu , Yun He , Yongping Xie , Xing Wang , Guobao Zhang , Nathanael Schiander Gray
- 申请人： Taebo Sim , Truc Ngoc Nguyen , Baogen Wu , Yun He , Yongping Xie , Xing Wang , Guobao Zhang , Nathanael Schiander Gray
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 国际申请： PCT/US08/67290 WO 20080618
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D239/94 ; A61K31/517 ; C12N5/00 ; A61P35/00 ; A61P35/04 ; A61P19/02 ; A61P17/06 ; A61P37/00 ; C07D239/88 ; C07D413/14 ; C07D413/12
摘要：
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα, p38, Src, SIK, Syk, Tie2 and TrkB kinases.
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IPC分类:
