发明申请
- 专利标题： Molecular Probe for Imaging of Pancreatic Islets and Use of the Same
- 专利标题（中）： 胰岛成像用分子探针及其用途
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申请号： US12872837申请日： 2010-08-31
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公开(公告)号： US20110059483A1公开(公告)日： 2011-03-10
- 发明人: Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人地址： JP Kyoto JP Kyoto
- 专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人地址： JP Kyoto JP Kyoto
- 优先权： JP2009-204769 20090904; JPPCT/JP2010/054450 20100316
- 主分类号： C12Q1/04
- IPC分类号： C12Q1/04 ; C07K14/00 ; C12Q1/06
摘要：
To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides; polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides; Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (5) B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (9) where X in the formulae (1) and (5) and B—in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene group.