发明申请
- 专利标题： MODULATION OF FACTOR 9 EXPRESSION
- 专利标题（中）： 因子9表达式的调制
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申请号： US12742076申请日： 2008-11-05
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公开(公告)号： US20110059895A1公开(公告)日： 2011-03-10
- 发明人: Susan M. Freier , Brett P. Monia , Hong Zhang , Chenguang Zhao
- 申请人： Susan M. Freier , Brett P. Monia , Hong Zhang , Chenguang Zhao
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 国际申请： PCT/US08/82527 WO 20081105
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07H21/00 ; C07H21/04 ; A61K31/7088 ; A61P7/02 ; A61P9/10 ; A61P9/00
摘要：
Disclosed herein are antisense compounds and methods for decreasing Factor 9 and increasing clotting time in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 9 include thrombosis, embolism, thromoboembolism such as deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke.