发明申请
US20110064795A1 Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
有权
针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性
- 专利标题: Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
- 专利标题(中): 针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性
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申请号: US12870893申请日: 2010-08-30
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公开(公告)号: US20110064795A1公开(公告)日: 2011-03-17
- 发明人: Pierre-Francois Tosi , Claudine Madoulet , Claude Yves Nicolau , David T. Hickman
- 申请人: Pierre-Francois Tosi , Claudine Madoulet , Claude Yves Nicolau , David T. Hickman
- 申请人地址: CH Lausanne
- 专利权人: AC IMMUNE SA
- 当前专利权人: AC IMMUNE SA
- 当前专利权人地址: CH Lausanne
- 优先权: FR0309188000 20030725
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K39/00 ; A61K38/10 ; A61P35/02 ; A61K9/133 ; A61P35/00
摘要:
The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies.
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