发明申请
- 专利标题： C-Met Modulators and Method of Use
- 专利标题（中）： C-Met调制器和使用方法
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申请号： US12911442申请日： 2010-10-25
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公开(公告)号： US20110077233A1公开(公告)日： 2011-03-31
- 发明人: Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wei Xu
- 申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wei Xu
- 申请人地址： US CA South San Francisco
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; C07D401/12 ; A61K31/4709 ; C07D417/12 ; C07D403/12 ; C07D239/94 ; A61K31/47 ; C07D413/12 ; A61K31/5377 ; A61P35/00 ; A61P9/00 ; A61P37/02 ; A61P29/00 ; C12Q1/48 ; C12N5/02
摘要：
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
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