A method for enhanced location sensing based on topology constraints. A potential position value and a corresponding probability value with respect to an observed position data of an object within a structure can be calculated utilizing a normal probability distribution function. Thereafter, an optimal route between adjacent observed time periods may be calculated utilizing a heuristic search algorithm. The potential position value and the optimal route can be calculated by accessing a pre-installed topology data associated with the structure. An optimization problem can then be solved to refine the observed position data. The position between a pair of observed time periods can be interpolated and the position of the object before a next observed time can be predicted by interpolation based on the spatial constraints.