发明申请
US20110085970A1 ANTI-B7H4 MONOCLONAL ANTIBODY-DRUG CONJUGATE AND METHODS OF USE
审中-公开
抗B7H4单克隆抗体药物联合使用方法
- 专利标题: ANTI-B7H4 MONOCLONAL ANTIBODY-DRUG CONJUGATE AND METHODS OF USE
- 专利标题(中): 抗B7H4单克隆抗体药物联合使用方法
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申请号: US12745677申请日: 2008-11-26
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公开(公告)号: US20110085970A1公开(公告)日: 2011-04-14
- 发明人: Jonathan A. Terrett , Josephine M. Cardarelli , Chetana Rao-Naik , Bingliang Chen , David J. King
- 申请人: Jonathan A. Terrett , Josephine M. Cardarelli , Chetana Rao-Naik , Bingliang Chen , David J. King
- 国际申请: PCT/US2008/084923 WO 20081126
- 主分类号: A61K51/10
- IPC分类号: A61K51/10 ; C07K16/00 ; A61K39/395 ; A61P35/00
摘要:
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided, immunoconjugates, including antibody-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.