发明申请
- 专利标题： THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS
- 专利标题（中）： 噻唑烷酮能量限制 - 物理试剂
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申请号： US12901782申请日： 2010-10-11
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公开(公告)号： US20110086895A1公开(公告)日： 2011-04-14
- 发明人: Ching-Shih Chen , Jih-Hwa Guh
- 申请人： Ching-Shih Chen , Jih-Hwa Guh
- 申请人地址： US OH Columbus
- 专利权人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人地址： US OH Columbus
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; A61P3/10 ; A61P37/02
摘要：
A method of inhibiting glycolysis in a subject by administering a pharmaceutical composition including a thiazolidinedione derivative to the subject is described. The thiazolidinedione derivatives are effective energy restriction mimetic agents, and can therefore be used to treat or prevent cancer in a subject, treat metabolic disorder, or increase the longevity of a subject. Various thiazolidinedione derivatives are also suitable for activating adenosine phosphate-activated protein kinase or inhibiting IL-6 expression.
公开/授权文献
- US08383656B2 Thiazolidinedione energy restriction-mimetic agents 公开/授权日：2013-02-26
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