发明申请
US20110091537A1 Anti-misuse solid oral pharmaceutical form provided with a specific modified release profile
审中-公开
提供具有特定修改释放特征的反滥用固体口服药物形式
- 专利标题: Anti-misuse solid oral pharmaceutical form provided with a specific modified release profile
- 专利标题(中): 提供具有特定修改释放特征的反滥用固体口服药物形式
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申请号: US12905387申请日: 2010-10-15
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公开(公告)号: US20110091537A1公开(公告)日: 2011-04-21
- 发明人: Catherine Castan , Anne-Sophie DAVIAUD-VENET
- 申请人: Catherine Castan , Anne-Sophie DAVIAUD-VENET
- 申请人地址: FR Venissieux
- 专利权人: Flamel Technologies
- 当前专利权人: Flamel Technologies
- 当前专利权人地址: FR Venissieux
- 优先权: FR0957270 20091016; IBPCT/IB2010/054674 20101015
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K31/485 ; A61K9/20 ; A61K9/48 ; A61K31/137
摘要:
The present invention relates to a solid oral pharmaceutical form, with modified release of at least one active ingredient, containing at least microparticles containing said active ingredient and at least one viscosifying agent in a form isolated from said microparticles of active ingredient, characterized in that said microparticles possess an average diameter ranging from 100 to 600 μm, and are formed by a core containing at least said active ingredient and coated with at least one coating layer, said core being formed by a support particle covered by a layer comprising at least said active ingredient, said coating layer being formed by a material composed of at least 25 to 70% by weight relative to the total weight of said coating, of at least one polymer A insoluble in water, 30 to 75% by weight relative to the total weight of said coating, of at least one polymer B insoluble in water below pH 5 and soluble in water above pH 7, and 0 to 25% by weight relative to the total weight of said coating, of at least one plasticizer, said polymers A and B being in a polymer(s) B/polymer(s) A weight ratio comprised between 0.25 and 4, and said coating layer representing at least 35% by weight, relative to the total weight of said microparticle.
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