A method for filling dual-chamber systems in pre-sterilizable carrier systems includes providing at least one washed, siliconized and sterilized dual-chamber system with respectively one separating element separating the two chambers from one another in a magazine, which accommodates the at least one dual-chamber system. The magazine is arranged in a container sealed with a closure element. The method additionally includes feeding the container into a clean room; opening the container and filling a first chamber of the at least one dual-chamber system; closing the first chamber with a gas-permeable closure element; and freeze drying the solution contained in the first chamber. The method further includes closing the first chamber with a closure element; filling a second chamber of the at least one dual-chamber system; closing the second chamber; and discharging the container from the clean room.