发明申请
US20110097264A1 RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT
审中-公开
使用多种甘氨酸作为胃肠吸收成像剂的放射性标记方法
- 专利标题： RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT
- 专利标题（中）： 使用多种甘氨酸作为胃肠吸收成像剂的放射性标记方法
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申请号： US12779328申请日： 2010-05-13
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公开(公告)号： US20110097264A1公开(公告)日： 2011-04-28
- 发明人: Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
- 申请人： Mei-Hui Wang , Wuu-Jyh Lin , Chuan-Yi Chien , Hung-Man Yu , Reiko Takasaka Lee , Yuan-Chuan Lee
- 申请人地址： TW Taoyuan County
- 专利权人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- 当前专利权人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- 当前专利权人地址： TW Taoyuan County
- 优先权： TW098136143 20091026
- 主分类号： A61K51/08
- IPC分类号： A61K51/08 ; C07K5/083 ; C07F5/00 ; A61K51/04
摘要：
A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.
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