发明申请
- 专利标题: Poly(Propargyl-L-Glutamate) and Derivatives Thereof
- 专利标题(中): 聚(炔丙基-L-谷氨酸)及其衍生物
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申请号: US12607592申请日: 2009-10-28
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公开(公告)号: US20110097419A1公开(公告)日: 2011-04-28
- 发明人: Paula T. Hammond , Amanda C. Engler , Hyung-il Lee
- 申请人: Paula T. Hammond , Amanda C. Engler , Hyung-il Lee
- 申请人地址: US MA Cambridge
- 专利权人: Massachusetts Institute of Technology
- 当前专利权人: Massachusetts Institute of Technology
- 当前专利权人地址: US MA Cambridge
- 主分类号: C08F126/06
- IPC分类号: C08F126/06 ; C07D263/44 ; C08G16/00 ; C08F38/00 ; A61K31/7105 ; A61K9/14
摘要:
A process of the present invention is directed toward conducting highly selective, high yield post-polymerization reactions on polypeptides to prepare functionalized polypeptides. In certain embodiments, the polypeptides can be prepared by ring opening polymerization of N-carboxyanhydrides. In certain embodiments, the post-polymerization reaction is a “click chemistry” reaction. In certain embodiment, the “click chemistry” reaction is a triazole-forming reaction involving an alkyne on the polypeptide and an azide.
公开/授权文献
- US08222359B2 Poly(propargyl-L-glutamate) and derivatives thereof 公开/授权日:2012-07-17