发明申请
- 专利标题： SULFONAMIDES AS ZAP-70 INHIBITORS
- 专利标题（中）： 磺酰胺作为ZAP-70抑制剂
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申请号： US12922163申请日： 2009-03-10
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公开(公告)号： US20110098288A1公开(公告)日： 2011-04-28
- 发明人: Jeremy Major , Richard John Harrison , Nigel Ramsden , David Middlemiss , Ulrich Kruse , Gerard Drewes
- 申请人： Jeremy Major , Richard John Harrison , Nigel Ramsden , David Middlemiss , Ulrich Kruse , Gerard Drewes
- 优先权： EP08152568.5 20080311
- 国际申请： PCT/EP2009/052789 WO 20090310
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; C07D239/48 ; C07D405/12 ; C07D417/12 ; C07D413/12 ; C07D401/12 ; C07D403/12 ; A61K31/538 ; A61K31/5377 ; A61K31/506 ; A61P37/00 ; A61P29/00 ; A61P37/08 ; A61P19/02 ; A61P25/00 ; A61P17/06 ; A61P1/00 ; A61P1/04 ; A61P11/06 ; A61P11/00
摘要：
The invention relates to compounds of formula (I) wherein R1 to R9 and R4a have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
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