发明申请
- 专利标题: FLUORESCENT PROBES
- 专利标题(中): 荧光探针
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申请号: US12914525申请日: 2010-10-28
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公开(公告)号: US20110098475A1公开(公告)日: 2011-04-28
- 发明人: Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
- 申请人: Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
- 申请人地址: JP Tokyo JP Tokyo
- 专利权人: Tetsuo NAGANO,SEKISUI MEDICAL CO., LTD.
- 当前专利权人: Tetsuo NAGANO,SEKISUI MEDICAL CO., LTD.
- 当前专利权人地址: JP Tokyo JP Tokyo
- 优先权: JP060080/2004 20040304
- 主分类号: C07D405/14
- IPC分类号: C07D405/14 ; C07D311/90 ; C07D311/82
摘要:
A fluorescent probe which is represented by the following formula (wherein R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R4 and R5 represent hydrogen atom, a halogen atom, or an alkyl group; R6 to R9 represent an alkyl group; R10 and R11 represent hydrogen atom, a halogen atom, or an alkyl group; M− represents a counter ion; and the combination of R1, R2, and R3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.
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