发明申请
US20110104055A1 SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES
审中-公开
取代的N-亚苄基苯甲酸和相关化合物用于治疗淀粉样变性疾病和综合征
- 专利标题： SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES
- 专利标题（中）： 取代的N-亚苄基苯甲酸和相关化合物用于治疗淀粉样变性疾病和综合征
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申请号： US12940330申请日： 2010-11-05
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公开(公告)号： US20110104055A1公开(公告)日： 2011-05-05
- 发明人: Alan Snow , Manfred Weigele , Lesley Larsen , Beth Nguyen , Thomas Lake , Gerardo Castillo , Virginia Sanders , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
- 申请人： Alan Snow , Manfred Weigele , Lesley Larsen , Beth Nguyen , Thomas Lake , Gerardo Castillo , Virginia Sanders , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
- 主分类号： A61K31/167
- IPC分类号： A61K31/167 ; C07C233/75 ; A61K51/00 ; A61P43/00
摘要：
Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.
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