公开(公告)号：US20150364146A1

公开(公告)日：2015-12-17

申请号：US14302083

申请日：2014-06-11

申请人： David Larsen ,  Dan Smith

发明人： David Larsen ,  Dan Smith

IPC分类号： G10L21/10

CPC分类号： G10L21/14 ,  G10L2021/065

摘要： A method for obtaining visual feedback for vowel quality is disclosed. By filtering and decomposing audio signals in formants, one or more software modules and/or applications may determine the type of phoneme in an audio signal that corresponds to a vowel. First and second formants may be measured in their frequencies; subsequently frequencies values of first formant and second formant may be assigned as X and Y coordinates, respectively. These (X,Y) coordinates may be used for graphing points and trajectories of the points in a Cartesian coordinate system while the user is pronouncing a vowel. Thus, graphic feedback for vowel pronunciation may be obtained.

摘要翻译： 公开了一种获得元音质量视觉反馈的方法。 通过对共振体中的音频信号进行滤波和分解，一个或多个软件模块和/或应用可以确定与元音对应的音频信号中的音素的类型。 第一和第二共振峰可以以其频率进行测量; 随后可将第一共振峰和第二共振峰的频率值分配为X和Y坐标。 这些（X，Y）坐标可以用于在用户发音元音时在笛卡尔坐标系中的点的图形点和轨迹。 因此，可以获得元音发音的图形反馈。

公开(公告)号：US20120181937A1

公开(公告)日：2012-07-19

申请号：US13282108

申请日：2011-10-26

申请人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

IPC分类号： H05B37/02

CPC分类号： G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

摘要： A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.

摘要翻译： 在生物分析或其他系统中的计量剂量照明的系统和方法包括可以在测量快速生物活性所需的短曝光时间内提供优化量的激发光的照明系统或子系统。 可以精确测量光量以提供定量结果。 可以精确地控制光通量以产生规定的最小量的光，以便减少对荧光和样品的不利的照明效果。 该系统和方法在任何质量控制，分析或评估环境中都特别有用。 典型的研发应用包括质量控制，仪器校准和光输出标准化; 而临床和诊断应用可以包括用于诊断，治疗和/或治疗评估的临床监测，生物测定校准和控制。

公开(公告)号：US20120181936A1

公开(公告)日：2012-07-19

申请号：US13007535

申请日：2011-01-14

申请人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

IPC分类号： H05B37/02

CPC分类号： H05B33/0869 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419

摘要： A system and method for metered dosage illumination in a bioanalysis or other system. In accordance with an embodiment, an illumination system or subsystem is described that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can also be precisely controlled to generate only a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. Although the examples herein illustrate the providing of metered dosage illumination in the context of a bioanalysis system, the techniques can be similarly used to provide metered dosage illumination in the context of other types of system.

摘要翻译： 生物分析或其他系统中计量剂量照明的系统和方法。 根据实施例，描述了可以在测量快速生物活性所需的短曝光时间内提供优化量的激发光的照明系统或子系统。 可以精确测量光量以提供定量结果。 也可以精确地控制光通量以仅产生规定的最小量的光，以便减少对荧光和样品的不利的照明效果。 虽然本文的实施例说明了在生物分析系统的背景下提供计量剂量照明，但是这些技术可以类似地用于在其他类型的系统的上下文中提供计量剂量照明。

公开(公告)号：US08213438B2

公开(公告)日：2012-07-03

申请号：US10875995

申请日：2004-06-24

申请人： James David Larsen ,  Paul Jonathan Rodman

发明人： James David Larsen ,  Paul Jonathan Rodman

IPC分类号： H04L12/56

CPC分类号： H04W40/24 ,  H04W24/00 ,  H04W40/02 ,  H04W40/10 ,  H04W40/246 ,  H04W74/00 ,  H04W84/042 ,  H04W84/22 ,  H04W88/04 ,  H04W88/08 ,  Y02D70/142 ,  Y02D70/30 ,  Y02D70/326

摘要： The invention relates to a method of operating a communication network, the network comprising a plurality of stations which are able to transmit data to and receive data from one another so that a message comprising a plurality of data packets is sent from an originating station to a destination station via at least one opportunistically selected intermediate station. The method makes use of probe signals transmitted from each station on a selected probing channel to which other stations respond to indicate their availability as destination or intermediate stations. A Request to Send message is sent, with a Clear to Send message returned by an available station. The station with data to send opportunistically selects an available station and the selected station uses a Packet Acknowledge message to confirm successful reception of the transmitted data packet. An End-to-End Acknowledge message is sent by the originating station, directly or indirectly, to confirm receipt of said data packets.

摘要翻译： 本发明涉及一种操作通信网络的方法，该网络包括能够将数据彼此传输和接收数据的多个站，使得包括多个数据分组的消息从始发站发送到 目的地站经由至少一个机会选择的中间站。 该方法利用从其他站响应的所选探测信道上的每个站发送的探测信号，以指示其作为目的地或中间站的可用性。 发送请求发送消息，具有由可用站返回的清除发送消息。 具有要发送的数据的站机会地选择可用站，并且所选站使用分组确认消息来确认成功接收所发送的数据分组。 端到端确认消息由发起站直接或间接地发送以确认接收到所述数据分组。

公开(公告)号：US20110104055A1

公开(公告)日：2011-05-05

申请号：US12940330

申请日：2010-11-05

申请人： Alan Snow ,  Manfred Weigele ,  Lesley Larsen ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo ,  Virginia Sanders ,  Rex T. Weavers ,  Stephen Lorimer ,  David Larsen ,  David L. Coffen ,  Charlotte Coffen

发明人： Alan Snow ,  Manfred Weigele ,  Lesley Larsen ,  Beth Nguyen ,  Thomas Lake ,  Gerardo Castillo ,  Virginia Sanders ,  Rex T. Weavers ,  Stephen Lorimer ,  David Larsen ,  David L. Coffen ,  Charlotte Coffen

IPC分类号： A61K31/167 ,  C07C233/75 ,  A61K51/00 ,  A61P43/00

CPC分类号： C07C235/56

摘要： Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

摘要翻译： 化合物及其药学上可接受的盐，它们的合成和标记，含有它们的药物组合物及其在治疗淀粉样疾病中的用途，包括A＆bgr; 提供淀粉样变性，例如在阿尔茨海默病中观察到的，IAPP淀粉样变性，例如在2型糖尿病中观察到的，以及突触核蛋白病，例如在帕金森病中观察到的，并且制备用于这种治疗的药物。 还提供了所公开的化合物作为淀粉样蛋白和突触核蛋白的体内成像和检测的成像剂和方法的用途。

公开(公告)号：US20100034134A1

公开(公告)日：2010-02-11

申请号：US12518905

申请日：2007-12-14

申请人： James David Larsen

发明人： James David Larsen

IPC分类号： H04B7/14 ,  H04B15/00

CPC分类号： H04W16/28 ,  H04W16/32 ,  H04W48/12 ,  H04W84/12

摘要： The invention provides a method of operating a communication network and a network itself. The network comprises a plurality of wireless stations, each station being able to transmit and receive data so that the network can transmit a message comprising a plurality of data packets from an originating station to a destination station via at least one intermediate station. At least some of the stations have a controllable antenna system operable to direct a null selectively. The method includes selecting, at each station, one or more probing channels for the transmission of probe signals to other stations. At stations having a controllable antenna system, the presence of interference on said one or more probing channels is detected, and one or more nulls are selectively directed towards the source or sources of the interference. Typically, a null is directed towards a source of interference where the level of the interference exceeds a predetermined level. Each station transmits neighbor gathering probe signals on the selected probing channel or channels, and other stations which receive the neighbor gathering probe signals from a probing station respond directly or indirectly to thereby indicate to the probing station their availability as destination or intermediate neighbor stations. The presence of the nulls affects the ability of other stations to receive the neighbor gathering probe signals, and the resulting variations in the connectivity between stations provides variations in the availability of neighbor stations to each station.

摘要翻译： 本发明提供了一种操作通信网络和网络本身的方法。 网络包括多个无线站，每个站能够发送和接收数据，使得网络可以经由至少一个中间站将包括多个数据分组的消息从发起站发送到目的地站。 至少一些站具有可操作以有选择地引导无效的可控天线系统。 该方法包括在每个站点选择用于将探测信号传输到其它站的一个或多个探测信道。 在具有可控天线系统的站处，检测在所述一个或多个探测信道上的干扰的存在，并且一个或多个零点被选择性地指向干扰源或源。 通常，零点指向干扰源，其中干扰电平超过预定电平。 每个站在所选择的探测信道或信道上发送相邻采集探测信号，并且从探测站接收邻居采集探测信号的其他站直接或间接地进行响应，从而向探测站指示其作为目的地或中间邻居站的可用性。 空值的存在影响其他站接收邻居采集探测信号的能力，并且由此产生的站间连通性的变化提供了对各个站的相邻站的可用性的变化。

公开(公告)号：US20070023037A1

公开(公告)日：2007-02-01

申请号：US11191272

申请日：2005-07-27

申请人： David Larsen ,  Zhi Xu

发明人： David Larsen ,  Zhi Xu

IPC分类号： A61M11/00

CPC分类号： A61M11/005 ,  A61M11/001 ,  A61M16/1095 ,  G01N30/74 ,  G01N30/84 ,  G01N2030/847 ,  G01N21/47

摘要： A focused droplet nebulizer of the invention produces substantially uniform droplets of a predetermined size. Droplets are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a drift tube. A piezo membrane micro pump acts in response to an electrical control signal to force a droplet out of the outlet orifice. The nebulizer can operate at frequencies permitting a stream of individual droplets of the predetermined size to be sent along the substantially non-divergent path in the drift tube in a preferred embodiment ELSD device.

摘要翻译： 本发明的聚焦液滴雾化器产生预定尺寸的基本均匀的液滴。 通过室的收缩将液滴从小出口孔推出。 液滴可以在漂移管中的基本上不发散的路径上承载。 压电膜微泵响应于电控制信号而起作用以迫使液滴离开出口孔。 在优选实施例的ELSD装置中，雾化器可以以允许预定尺寸的各个液滴流沿漂移管中的基本非发散路径发送的频率工作。

公开(公告)号：US20060245870A1

公开(公告)日：2006-11-02

申请号：US11415763

申请日：2006-05-02

申请人： Laurence Blake ,  Philip Rombult ,  Libor Krupica ,  David Larsen ,  James Folsom ,  Ross Freeman ,  Roger Jacques ,  Robert Ring ,  Gerald Smith

发明人： Laurence Blake ,  Philip Rombult ,  Libor Krupica ,  David Larsen ,  James Folsom ,  Ross Freeman ,  Roger Jacques ,  Robert Ring ,  Gerald Smith

IPC分类号： B65B69/00

CPC分类号： B65H1/266 ,  B41C1/1083 ,  B65H1/14 ,  B65H3/0816 ,  B65H3/44 ,  B65H3/54 ,  B65H2301/42256 ,  B65H2405/332 ,  B65H2405/35 ,  B65H2511/10 ,  B65H2511/20 ,  B65H2511/40 ,  B65H2701/1719 ,  B65H2701/18264 ,  B65H2701/1928 ,  B65H2801/21 ,  G03F7/20 ,  G03F7/2014 ,  G03F7/2055 ,  G03F7/24 ,  B65H2220/01 ,  B65H2220/02 ,  B65H2220/11

摘要： An apparatus is provided for positioning a plurality of cassettes within an automated printing plate handler. In a plate handler, a plurality of cassettes each contain a supply of printing plates for delivery to an automatic plate-recording device. The apparatus includes a separate support table for supporting each of the plurality of cassettes within the plate handler and an elevator device for moving each of the support tables along a vertical axis of the automated plate handler. The automated plate handler is configured to automatically position a selected cassette in a first position to facilitate removal of the cassette from the handler. The plate handler further includes a platform, which substantially forms an extension of the support table supporting the selected cassette in the first position. The platform provides a second position, at which the selected cassette is to be one of, loaded or unloaded. The selected cassette may be filled with a new supply of plates on the platform or the selected cassette may be removed from the platform and replaced by another cassette.

摘要翻译： 提供了一种用于将多个盒定位在自动印版处理器内的装置。 在板处理机中，多个盒每个都包含用于传送到自动板记录装置的印版供应。 该装置包括用于支撑板处理器内的多个盒中的每一个的单独的支撑台和用于沿着自动板处理器的垂直轴移动每个支撑台的升降装置。 自动化板处理器被配置为将所选择的盒自动定位在第一位置以便于从处理器移除盒。 板处理器还包括平台，其基本上形成支撑台的支撑台的第一位置的延伸部。 该平台提供第二位置，在该位置，所选择的盒式磁带将被装载或卸载。 所选择的盒可以在平台上填充新的板供应，或者所选择的盒可以从平台移除并被另一个盒替换。

公开(公告)号：US20060218086A1

公开(公告)日：2006-09-28

申请号：US11148959

申请日：2005-06-08

申请人： Heather Campbell ,  Warren Croce ,  John Flora ,  Matthew Homier ,  Laxmi Kaushik ,  David Larsen ,  Costin Stefanescu

发明人： Heather Campbell ,  Warren Croce ,  John Flora ,  Matthew Homier ,  Laxmi Kaushik ,  David Larsen ,  Costin Stefanescu

IPC分类号： G06Q40/00

CPC分类号： G06Q10/10 ,  G06Q20/10 ,  G06Q40/00

摘要： Field values such as payee names from downloaded transaction records are automatically renamed when appropriate, to make them consistent with corrected field values, such as actual payee names. If a downloaded field value corresponds to an alias for an corrected field value, the downloaded value is re-placed with the corrected field value. If a renaming rule applies to a downloaded field value, the downloaded field value is replaced according to the renaming rule. The invention automatically generates aliases and/or renaming rules when appropriate.

摘要翻译： 字段值（如下载的交易记录中的收款人姓名）将在适当时自动重命名，以使其与已更正的字段值（例如实际收款人姓名）保持一致。 如果已下载的字段值对应于已更正字段值的别名，则将下载的值与已更正的字段值重新放置。 如果重命名规则适用于下载的字段值，则根据重命名规则替换下载的字段值。 本发明适当时自动生成别名和/或重命名规则。

公开(公告)号：US5921818A

公开(公告)日：1999-07-13

申请号：US881030

申请日：1997-06-23

申请人： Wayne David Larsen ,  Julian Robert Pharney

发明人： Wayne David Larsen ,  Julian Robert Pharney

IPC分类号： H05K1/02 ,  H05K3/20 ,  H01R23/02

CPC分类号： H01R13/6467 ,  H01R13/6477 ,  H05K1/0216 ,  H05K3/202 ,  Y10S439/941

摘要： A high frequency electrical connector includes a number of input terminals and output terminals that are interconnected by three metallic lead frames mounted on a dielectric spring block. The lead frames comprise flat elongated conductors, each terminating in a spring contact at one end and an insulation displacement connector at the other end. The lead frames are mounted on top of each other and their conductors are generally parallel and close to each other. Selected conductors of the lead frames crossover each other when they are mounted on the spring block but are prevented from making contact with each other at the crossover point. One pair of adjacent conductors are spaced a first distance from each other up to the crossover point, and a second, greater distance from each other beyond the crossover point for a portion of their lengths. The conductors of the one pair cross each other at a second crossover point. The conductors of a second conductor pair are crossed over one of the conductors of a third conductor pair and are closely spaced at the crossover point.

摘要翻译： 高频电连接器包括通过安装在介电弹簧块上的三个金属引线框架互连的多个输入端子和输出端子。 引线框架包括平坦的细长导体，每个端子在一端处于弹簧触点和另一端处的绝缘位移连接器。 引线框架安装在彼此的顶部，并且它们的导体大致平行并且彼此靠近。 引线架的选定导体在安装在弹簧块上时彼此交叉，但是防止在交叉点处彼此接触。 一对相邻的导体彼此间隔开直到交叉点，并且相对于它们的长度的一部分彼此超过交叉点的第二较大距离。 一对的导体在第二个交叉点处彼此交叉。 第二导体对的导体跨过第三导体对的导体中的一个，并且在交叉点处紧密间隔开。