发明申请
- 专利标题： HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS
- 专利标题（中）： 作为HDAC抑制剂的杂环衍生物
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申请号： US12997191申请日： 2009-06-08
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公开(公告)号： US20110105474A1公开(公告)日： 2011-05-05
- 发明人: Florian Thaler , Mario Varasi , Stefania Gagliardi , Andrea Colombo , Saverio Minucci , Ciro Mercurio
- 申请人： Florian Thaler , Mario Varasi , Stefania Gagliardi , Andrea Colombo , Saverio Minucci , Ciro Mercurio
- 专利权人： DAC S.r.l.
- 当前专利权人： DAC S.r.l.
- 优先权： EP08157857.7 20080609
- 国际申请： PCT/EP09/57042 WO 20090608
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; A61K31/55 ; A61K31/506 ; A61K31/496 ; A61K31/444 ; A61K31/4545 ; A61K31/4439 ; A61K31/407 ; C07D401/14 ; C07D401/06 ; C07D295/192 ; C07D471/10 ; C07D471/04 ; C07D401/04 ; C07D487/08 ; C07D241/04 ; A61P35/00
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond; R1 is hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or C1 C6 haloalkoxy; R2, R3 are, independently, hydrogen; C1-C6 alkyl; aryl; or taken together with the carbon atoms to which they are bound form a bridged bicyclic ring or a fused heterocycle; X is CH or nitrogen; Y is a bond, oxygen, (CH2)mCR4R5(CH2)n, or (CH2)oNR6(CH2)p; m, n, o, p, R4, R5 and R6 are as further defined in the specification; and pharmaceutical acceptable salts thereof.
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