发明申请
- 专利标题： INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS
- 专利标题（中）： 基于受体的CRTH2拮抗剂
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申请号： US12938479申请日： 2010-11-03
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公开(公告)号： US20110105509A1公开(公告)日： 2011-05-05
- 发明人: Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
- 申请人： Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
- 申请人地址： US NJ Madison
- 专利权人： Wyeth, LLC
- 当前专利权人： Wyeth, LLC
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/502
- IPC分类号： A61K31/502 ; C07D403/04 ; A61K31/501 ; C07D401/06 ; A61K31/4439 ; C07D403/14 ; C07D403/06 ; A61K31/4725 ; C07D417/14 ; C07D401/14 ; A61P11/00 ; A61P1/00 ; A61P17/00 ; A61P29/00 ; A61P37/06 ; A61P37/08 ; C12N5/02
摘要：
Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.