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公开(公告)号:US20110105509A1
公开(公告)日:2011-05-05
申请号:US12938479
申请日:2010-11-03
申请人: Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
发明人: Neelu Kaila , Eddine Saiah , Bruce Christopher Follows , Adrian Huang , Kristin Marie Janz , Michael Dennis Lowe , Alessandro Fabio Moretto , Jennifer Romanic Thomason , Tarek Suhayl Mansour , Cara Margaret May Williams
IPC分类号: A61K31/502 , C07D403/04 , A61K31/501 , C07D401/06 , A61K31/4439 , C07D403/14 , C07D403/06 , A61K31/4725 , C07D417/14 , C07D401/14 , A61P11/00 , A61P1/00 , A61P17/00 , A61P29/00 , A61P37/06 , A61P37/08 , C12N5/02
CPC分类号: C07D403/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/14
摘要: Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.
摘要翻译: 公开了式(I)的化合物:其可用作CRTH2受体的拮抗剂。 还公开了含有式(I)化合物和式(I)化合物用于治疗对抑制内源性配体与CRTH2受体的结合有反应的疾病或病症的药物组合物。 进一步描述制备和使用这些化合物的方法。