发明申请
US20110105740A1 SOLUBLE TNF RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE
审中-公开
可溶性TNF受体及其在治疗疾病中的应用
- 专利标题： SOLUBLE TNF RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE
- 专利标题（中）： 可溶性TNF受体及其在治疗疾病中的应用
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申请号： US12871625申请日： 2010-08-30
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公开(公告)号： US20110105740A1公开(公告)日： 2011-05-05
- 发明人: PETER L. SAZANI
- 申请人： PETER L. SAZANI
- 专利权人： Santaris Pharma A/S, a Denmark corporation,University of North Carolina at Chapel Hill, a North Carolina corporation,Ercole Biotech, Inc., a Delaware corporation
- 当前专利权人： Santaris Pharma A/S, a Denmark corporation,University of North Carolina at Chapel Hill, a North Carolina corporation,Ercole Biotech, Inc., a Delaware corporation
- 主分类号： C07H21/00
- IPC分类号： C07H21/00
摘要：
The present invention relates to tumor necrosis factor (TNF) antagonists and corresponding nucleic acids derived from tumor necrosis factor receptors (TNFRs) and their use in the treatment of inflammatory diseases. These proteins are soluble secreted decoy receptors that bind to TNF and prevent TNF from signaling to cells. In particular, the proteins are mammalian TNFRs that lack exon 7 and which can bind TNF and can act as a TNF antagonist.