- 专利标题： SPIRO-OXINDOLE MDM2 ANTAGONISTS
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申请号： US12945511申请日： 2010-11-12
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公开(公告)号： US20110112052A1公开(公告)日： 2011-05-12
- 发明人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- 申请人： Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- 申请人地址： US MI Ann Arbor
- 专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人地址： US MI Ann Arbor
- 主分类号： C07D487/10
- IPC分类号： C07D487/10 ; A61K31/407 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/675 ; A61P1/00 ; A61P35/04
摘要：
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
公开/授权文献
- US08518984B2 Spiro-oxindole MDM2 antagonists 公开/授权日：2013-08-27
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