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公开(公告)号:US20110112052A1
公开(公告)日:2011-05-12
申请号:US12945511
申请日:2010-11-12
申请人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
发明人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
IPC分类号: C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61P1/00 , A61P35/04
CPC分类号: C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D471/20 , C07D491/107 , C07D495/10 , C07F9/6561 , A61K2300/00
摘要: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
摘要翻译: 本文提供了药物化学领域中的化合物,组合物和方法。 本文提供的化合物和组合物涉及作为p53和MDM2之间的相互作用的拮抗剂的螺 - 羟吲哚,以及它们作为治疗癌症和其它疾病的治疗剂的用途。
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公开(公告)号:US08518984B2
公开(公告)日:2013-08-27
申请号:US12945511
申请日:2010-11-12
申请人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
发明人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
IPC分类号: C07D487/10 , A61K31/4015
CPC分类号: C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D471/20 , C07D491/107 , C07D495/10 , C07F9/6561 , A61K2300/00
摘要: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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公开(公告)号:US20120122947A1
公开(公告)日:2012-05-17
申请号:US13294315
申请日:2011-11-11
申请人: Shaomeng Wang , Yujun Zhao , Wei Sun , Sanjeev Kumar , Lance Leopold , Laurent Debussche , Cedric Barriere , Jean-Christophe Carry , Kwame Amaning
发明人: Shaomeng Wang , Yujun Zhao , Wei Sun , Sanjeev Kumar , Lance Leopold , Laurent Debussche , Cedric Barriere , Jean-Christophe Carry , Kwame Amaning
IPC分类号: A61K31/407 , A61P35/00 , A61P35/02 , C07D487/10
CPC分类号: A61N5/10 , A61K31/407 , A61K45/06 , C07D487/10 , A61K2300/00
摘要: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
摘要翻译: 本文提供了药物化学领域中的化合物,组合物和方法。 本文提供的化合物和组合物涉及用作p53和MDM2之间相互作用的拮抗剂的螺 - 羟基吲哚,以及它们作为治疗癌症和其它疾病的治疗剂的用途。
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4.
公开(公告)号:US08691184B2
公开(公告)日:2014-04-08
申请号:US13356763
申请日:2012-01-24
申请人: Shaomeng Wang , Haibin Zhou , Jianfang Chen , Angelo Aguilar , Jennifer L. Meagher , Duxin Sun , Chao-Yie Yang , Liu Liu , Longchuan Bai , Donna McEachem , Jeanne Stuckey , Xiaoqin Li
发明人: Shaomeng Wang , Haibin Zhou , Jianfang Chen , Angelo Aguilar , Jennifer L. Meagher , Duxin Sun , Chao-Yie Yang , Liu Liu , Longchuan Bai , Donna McEachem , Jeanne Stuckey , Xiaoqin Li
IPC分类号: A61K51/00 , A61K31/5377 , A61K31/496 , C07D413/14 , C07D403/12 , C07D401/14 , C07D403/10 , C07D405/10 , A61P35/00 , A61K31/5513 , C07D471/04
CPC分类号: C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要: Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译: 公开了Bcl-2 / Bcl-xL的抑制剂及其组合物。 还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中Bcl-2 / Bcl-xL的抑制提供益处的疾病和病症的方法,如癌症。
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5.
公开(公告)号:US20120189539A1
公开(公告)日:2012-07-26
申请号:US13356763
申请日:2012-01-24
申请人: Shaomeng Wang , Haibin Zhou , Jianfang Chen , Angelo Aguilar , Jennifer L. Meagher , Duxin Sun , Chao-Yie Yang , Liu Liu , Longchuan Bai , Donna McEachem , Jeanne Stuckey , Xiaoqin Li
发明人: Shaomeng Wang , Haibin Zhou , Jianfang Chen , Angelo Aguilar , Jennifer L. Meagher , Duxin Sun , Chao-Yie Yang , Liu Liu , Longchuan Bai , Donna McEachem , Jeanne Stuckey , Xiaoqin Li
IPC分类号: A61K51/00 , A61K31/5377 , A61K31/496 , C07D413/14 , C07D403/12 , C07D401/14 , C07D403/10 , C07D405/10 , A61P35/00 , A61K31/5513 , C07D471/04
CPC分类号: C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要: Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译: 公开了Bcl-2 / Bcl-xL的抑制剂及其组合物。 还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中Bcl-2 / Bcl-xL的抑制提供益处的疾病和病症的方法,如癌症。
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公开(公告)号:US07737174B2
公开(公告)日:2010-06-15
申请号:US11848089
申请日:2007-08-30
申请人: Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
发明人: Shaomeng Wang , Dongguang Qin , Jiangyong Chen , Shanghai Yu
IPC分类号: A61K31/404 , C07D209/30 , C07D209/34
CPC分类号: C07D487/10 , C07D491/10
摘要: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
摘要翻译: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长,诱导细胞死亡,诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号:US08222288B2
公开(公告)日:2012-07-17
申请号:US12815113
申请日:2010-06-14
申请人: Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
发明人: Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
IPC分类号: A61K31/407 , C07D487/10
CPC分类号: C07D487/10 , C07D491/107 , C12N5/0693 , C12N2501/48
摘要: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
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公开(公告)号:US20120289494A1
公开(公告)日:2012-11-15
申请号:US13469928
申请日:2012-05-11
IPC分类号: A61K31/407 , A61K31/5377 , A61P35/00 , A61K31/438 , A61K31/41 , C07D487/10 , C07D471/20
CPC分类号: C07D487/10
摘要: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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公开(公告)号:US08629141B2
公开(公告)日:2014-01-14
申请号:US13469928
申请日:2012-05-11
IPC分类号: A61K31/4015 , C07D209/96 , C07D273/04 , C07D401/14
CPC分类号: C07D487/10
摘要: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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公开(公告)号:US20100317661A1
公开(公告)日:2010-12-16
申请号:US12815113
申请日:2010-06-14
申请人: Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
发明人: Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
IPC分类号: A61K31/5377 , C07D487/10 , A61K31/407 , C12N5/00 , A61P35/00 , A61P17/14 , A61P1/00 , A61K31/496 , A61K31/4178
CPC分类号: C07D487/10 , C07D491/107 , C12N5/0693 , C12N2501/48
摘要: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
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