发明申请
- 专利标题： Pharmaceutical Compositions and Solid Forms
- 专利标题（中）： 药物组合物和固体形式
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申请号： US12827218申请日： 2010-06-30
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公开(公告)号： US20110112121A1公开(公告)日： 2011-05-12
- 发明人: Joerg BERGHAUSEN , Claire HAUG , Michael HERBIG , Bin HU , Stéphane JONAT , Rajender LELETI , Josef Gottfried MEINGASSNER , Stéphanie MONNIER , Matthias NAPP , Mahavir PRASHAD , Anton STÜTZ , Ranjit THAKUR
- 申请人： Joerg BERGHAUSEN , Claire HAUG , Michael HERBIG , Bin HU , Stéphane JONAT , Rajender LELETI , Josef Gottfried MEINGASSNER , Stéphanie MONNIER , Matthias NAPP , Mahavir PRASHAD , Anton STÜTZ , Ranjit THAKUR
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61P17/00 ; A61P17/06 ; C07D239/02
摘要：
The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide.
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