发明申请
- 专利标题: Enhanced Protein Production in Bacillus
- 专利标题(中): 增强芽孢杆菌中的蛋白质生产
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申请号: US12743187申请日: 2008-12-19
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公开(公告)号: US20110117598A1公开(公告)日: 2011-05-19
- 发明人: Marguerite A. Cervin , Eugenio Ferrari , Scott D. Power
- 申请人: Marguerite A. Cervin , Eugenio Ferrari , Scott D. Power
- 申请人地址: US CA Palo Alto
- 专利权人: DANISCO US INC.
- 当前专利权人: DANISCO US INC.
- 当前专利权人地址: US CA Palo Alto
- 国际申请: PCT/US2008/087633 WO 20081219
- 主分类号: C12P21/02
- IPC分类号: C12P21/02 ; C07H21/00 ; C07H21/04 ; C12N15/63 ; C12N1/21 ; C12N15/75 ; C12N9/00
摘要:
The present invention relates to cells that have been genetically manipulated to have an altered capacity to express and/or produce proteins of interest. In particular, the present invention relates to modified host cells of Gram-positive microorganisms, such as Bacillus species that are capable of overexpressing ymaH. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode YmaH, and the modified host cells comprising them. In particular, the present invention relates to compositions and methods of overexpressing YmaH for enhancing the expression and production of proteins of interest (e.g., proteases) in Bacillus species.
公开/授权文献
- US08512982B2 Enhanced protein production in Bacillus 公开/授权日:2013-08-20
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