发明申请
US20110118228A1 Enzymatic production or chemical synthesis and uses for 5,7-dienes and UVB conversion products thereof
审中-公开
酶制造或化学合成，并用于其5,7-二烯和UVB转化产物
- 专利标题： Enzymatic production or chemical synthesis and uses for 5,7-dienes and UVB conversion products thereof
- 专利标题（中）： 酶制造或化学合成，并用于其5,7-二烯和UVB转化产物
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申请号： US12807178申请日： 2010-08-30
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公开(公告)号： US20110118228A1公开(公告)日： 2011-05-19
- 发明人: Andrzej Slominski , Wei Li , Blazej Zbytek , Robert C. Tuckey , Jordan K. Zjawiony , Minh Ngoc Nguyen , Zorica Janjetovic , Michal A. Zmijewski , Trevor W. Sweatman , Duane D. Miller , Jianjun Chen , Arnold E. Postlethwaite
- 申请人： Andrzej Slominski , Wei Li , Blazej Zbytek , Robert C. Tuckey , Jordan K. Zjawiony , Minh Ngoc Nguyen , Zorica Janjetovic , Michal A. Zmijewski , Trevor W. Sweatman , Duane D. Miller , Jianjun Chen , Arnold E. Postlethwaite
- 主分类号： A61K31/57
- IPC分类号： A61K31/57 ; C07J5/00 ; C12N5/00 ; A61P35/00 ; A61P35/02 ; A61P17/00 ; A61P19/02 ; A61P3/10 ; A61P3/04 ; A61P9/10 ; C12P33/06
摘要：
Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.
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