发明申请
US20110124663A1 SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
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替代二氯吡啶和二氧化吡咯烷酮作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法
- 专利标题： SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
- 专利标题（中）： 替代二氯吡啶和二氧化吡咯烷酮作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法
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申请号： US12952640申请日： 2010-11-23
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公开(公告)号： US20110124663A1公开(公告)日： 2011-05-26
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K31/4439 ; C07D401/12 ; A61K31/4725 ; A61K31/438 ; C07D403/12 ; A61K31/427 ; C07D417/12 ; A61P25/00 ; A61P25/16 ; C12N5/071
摘要：
In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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