发明申请
US20110129896A1 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3Beta PROTEIN AND PROTEIN COMPLEXES
失效
GSK-3β蛋白和蛋白复合物GSK-3和晶体结构的抑制剂
- 专利标题： INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3Beta PROTEIN AND PROTEIN COMPLEXES
- 专利标题（中）： GSK-3β蛋白和蛋白复合物GSK-3和晶体结构的抑制剂
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申请号： US12944909申请日： 2010-11-12
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公开(公告)号： US20110129896A1公开(公告)日： 2011-06-02
- 发明人: Ernst ter Haar , Lovorka Swenson
- 申请人： Ernst ter Haar , Lovorka Swenson
- 申请人地址： US MA Cambridge
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA Cambridge
- 主分类号： C12N9/12
- IPC分类号： C12N9/12
摘要：
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
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