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1.发明申请Inhibitors of GSK-3 and crystal structures of GSK-3beta protein and protein complexes 失效GSK-3的抑制剂和GSK-3β蛋白和蛋白质复合物的晶体结构公开(公告)号：US20080262205A1
公开(公告)日：2008-10-23
申请号：US12079917
申请日：2008-03-28
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3β或其同源物的结合口袋的分子或分子复合物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合GSK-3β蛋白或其同系物的化合物的方法。 本发明还涉及可结晶组合物和包含GSK-3β蛋白或GSK-3β蛋白复合物的晶体。
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2.发明申请INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3Beta PROTEIN AND PROTEIN COMPLEXES 失效GSK-3β蛋白和蛋白复合物GSK-3和晶体结构的抑制剂公开(公告)号：US20110129896A1
公开(公告)日：2011-06-02
申请号：US12944909
申请日：2010-11-12
申请人： Ernst ter Haar , Lovorka Swenson
发明人： Ernst ter Haar , Lovorka Swenson
IPC分类号： C12N9/12
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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3.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 失效GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US08318467B2
公开(公告)日：2012-11-27
申请号：US12944909
申请日：2010-11-12
申请人： Ernst ter Haar , Lovorka Swenson
发明人： Ernst ter Haar , Lovorka Swenson
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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4.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 有权GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US07883881B2
公开(公告)日：2011-02-08
申请号：US12652152
申请日：2010-01-05
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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5.发明申请INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES 有权GSK-3和GSK-3BETA蛋白和蛋白复合物的晶体结构的抑制剂公开(公告)号：US20100227814A1
公开(公告)日：2010-09-09
申请号：US12652152
申请日：2010-01-05
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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6.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 失效GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US07666647B2
公开(公告)日：2010-02-23
申请号：US12079917
申请日：2008-03-28
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
摘要翻译： 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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