发明申请
US20110135640A1 IDENTIFICATION OF TUMOUR-ASSOCIATED CELL SURFACE ANTIGENS FOR DIAGNOSIS AND THERAPY
审中-公开
用于诊断和治疗的肿瘤相关细胞表面抗原的鉴定
- 专利标题: IDENTIFICATION OF TUMOUR-ASSOCIATED CELL SURFACE ANTIGENS FOR DIAGNOSIS AND THERAPY
- 专利标题(中): 用于诊断和治疗的肿瘤相关细胞表面抗原的鉴定
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申请号: US12969754申请日: 2010-12-16
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公开(公告)号: US20110135640A1公开(公告)日: 2011-06-09
- 发明人: ÖZLEM TÜRECI , UGUR SAHIN , GERD HELFTENBEIN , VOLKER SCHLÜTER
- 申请人: ÖZLEM TÜRECI , UGUR SAHIN , GERD HELFTENBEIN , VOLKER SCHLÜTER
- 申请人地址: DE MAINZ
- 专利权人: GANYMED PHARMACEUTICALS AG
- 当前专利权人: GANYMED PHARMACEUTICALS AG
- 当前专利权人地址: DE MAINZ
- 优先权: DE10344799.7 20030926
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K31/7088 ; A61K35/12 ; C07H21/04 ; C07K14/00 ; G01N33/53 ; C12Q1/68 ; A61P35/00
摘要:
The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof; (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions; (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.
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