发明申请
- 专利标题: Inhibitors of Cyclin Dependent Kinases and Their Use
- 专利标题(中): 细胞周期蛋白依赖性激酶抑制剂及其用途
-
申请号: US13026503申请日: 2011-02-14
-
公开(公告)号: US20110136873A1公开(公告)日: 2011-06-09
- 发明人: Bansi Lal , Kalpana Joshi , Sanjeev Kulkarni , Malcolm Mascarenhas , Shrikant Kamble , Maggie Joyce Rathos , Rajendrakumar Joshi
- 申请人: Bansi Lal , Kalpana Joshi , Sanjeev Kulkarni , Malcolm Mascarenhas , Shrikant Kamble , Maggie Joyce Rathos , Rajendrakumar Joshi
- 申请人地址: IN Mumbai (Maharashtra)
- 专利权人: PIRAMAL LIFE SCIENCES LTD.
- 当前专利权人: PIRAMAL LIFE SCIENCES LTD.
- 当前专利权人地址: IN Mumbai (Maharashtra)
- 优先权: IN616/MUM/2002 20020708
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; A61K31/4025 ; A61K31/4178 ; A61P35/00
摘要:
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ia) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ia) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.
公开/授权文献
- US08304449B2 Inhibitors of cyclin dependent kinases and their use 公开/授权日:2012-11-06
信息查询
IPC分类: