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    Inhibitors of cyclin dependent kinases and their use
    1.
    发明授权
    Inhibitors of cyclin dependent kinases and their use 有权
    细胞周期蛋白依赖性激酶抑制剂及其用途

    公开(公告)号：US07915301B2

    公开(公告)日：2011-03-29

    申请号：US11779577

    申请日：2007-07-18

    申请人： Bansi Lal ,  Kalpana Joshi ,  Sanjeev Kulkarni ,  Malcolm Mascarenhas ,  Shrikant Kamble ,  Maggie Joyce Rathos ,  Rajendrakumar Joshi

    发明人： Bansi Lal ,  Kalpana Joshi ,  Sanjeev Kulkarni ,  Malcolm Mascarenhas ,  Shrikant Kamble ,  Maggie Joyce Rathos ,  Rajendrakumar Joshi

    IPC分类号： A61K31/4025 ,  A61K31/353 ,  C07D405/04 ,  C07D311/32

    CPC分类号： A61K31/4025 ,  C07D405/04 ,  C07D405/14

    摘要： The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ia) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ia) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

    摘要翻译： 本发明涉及用于抑制细胞周期蛋白依赖性激酶的新化合物，更具体地，涉及式（Ia）的色烯酮衍生物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和A具有如 索赔。 本发明还涉及制备式（Ia）化合物的方法，抑制细胞周期蛋白依赖性激酶和抑制细胞增殖的方法，以使用式（Ia）化合物在治疗和预防疾病中的用途 ，其可以通过抑制细胞周期蛋白依赖性激酶（例如癌症）来治疗或预防使用式（Ia）化合物在制备用于这些疾病的药物中的用途。 本发明还涉及含有式（Ia）化合物的组合物，其单独或与另一种活性剂组合，与惰性载体混合或以其它方式结合，特别是含有式（Ia）化合物的药物组合物，其单独或 与另一种活性剂，药学上可接受的载体物质和辅助物质一起使用。

    Tricyclic guanidine derivatives as sodium-proton exchange inhibitors
    2.
    发明授权
    Tricyclic guanidine derivatives as sodium-proton exchange inhibitors 失效
    三环胍衍生物作为钠 - 质子交换抑制剂

    公开(公告)号：US07834001B2

    公开(公告)日：2010-11-16

    申请号：US11667583

    申请日：2005-11-08

    申请人： Bansi Lal ,  Swati Bal-Tembe ,  Usha Ghosh ,  Arun Kumar Jain ,  Tulsidas More

    发明人： Bansi Lal ,  Swati Bal-Tembe ,  Usha Ghosh ,  Arun Kumar Jain ,  Tulsidas More

    IPC分类号： C07D327/08 ,  A61K31/382

    CPC分类号： C07D327/08

    摘要： Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa; W is S(O)m; wherein Ra is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb is H, alkyl, OH, ORa or OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.

    摘要翻译： 公开了具有式1的稠合三环的胍衍生物，其中U是C（O），CR a R b，O，NR a或S（O）m; V是CRaRb或NRa; W为S（O）m; 其中R a是H，烷基，环烷基，烯基或芳烷基; Rb是H，烷基，OH，ORa或OCORa，m是整数0,1或2; R1，R2，R3，R4，R5，R6，R7和R8如本文所定义，条件是R 1，R 2，R 3，R 4，R 5，R 6，R 7或R 8中的至少一个是胍基或胍基羰基。 这些衍生物是钠 - 质子交换抑制剂，并且可用作治疗例如与缺血和再灌注相关的器官疾病，心律失常，心脏肥大，高血压，细胞增殖性疾病和糖尿病的药物。

    Process for the Preparation of Organic Materials
    5.
    发明申请
    Process for the Preparation of Organic Materials 审中-公开
    有机材料的制备工艺

    公开(公告)号：US20090017307A1

    公开(公告)日：2009-01-15

    申请号：US12122051

    申请日：2008-05-16

    申请人： Bansi Lal KAUL

    发明人： Bansi Lal KAUL

    IPC分类号： B32B27/10 ,  C09K11/06 ,  C08G12/24 ,  B32B27/38 ,  C07D209/46 ,  C07C69/76 ,  C07C229/62 ,  C07D403/12 ,  C07D471/04 ,  B32B27/34 ,  B32B27/40

    CPC分类号： C09B67/0061 ,  C08K5/0041 ,  C09B67/0013 ,  Y10T428/31511 ,  Y10T428/31551 ,  Y10T428/31725 ,  Y10T428/31783 ,  Y10T428/31786

    摘要： The present invention relates to advantageous processes for the manufacture of organic pigments and their precursors. The invention particularly relates to reactions carried out in an “All In One Reactor”® (Draiswerke GmbH, Germany), a kneader like the TurbuKneader® of the same company, a paddle dryer like the Turbudry® of the same company or a related system and thereby submitting the reaction mixtures to enhanced driving power as expressed by a Froude number >1, the reaction mixture being caused to react in high concentrations at elevated temperature.

    摘要翻译： 本发明涉及制备有机颜料及其前体的有利方法。 本发明特别涉及在“All In One Reactor”（Draiswerke GmbH，Germany）中进行的反应，如同一公司的TurbuKneader（）的捏合机，桨式干燥器，如Turbudry 相同的公司或相关系统，从而将反应混合物提供为由弗劳德数> 1表示的增强的驱动功率，使反应混合物在高温下以高浓度反应。

    Epindolidione pigments
    6.
    发明授权
    Epindolidione pigments 失效
    烯萘二酮颜料

    公开(公告)号：US07307170B2

    公开(公告)日：2007-12-11

    申请号：US10467041

    申请日：2002-02-06

    申请人： Bansi Lal Kaul ,  Bruno Piastra ,  Valérie Wolf ,  Frank Prokschy ,  Martin Ulrich Schmidt

    发明人： Bansi Lal Kaul ,  Bruno Piastra ,  Valérie Wolf ,  Frank Prokschy ,  Martin Ulrich Schmidt

    IPC分类号： C07D471/04

    CPC分类号： C07D403/12 ,  C07D235/26 ,  C07D471/04 ,  C07D471/14 ,  C09B15/00 ,  C09B57/00

    摘要： The epindolidione compounds of the general formula (I) in which A′, R2 and A have the meanings given in claim 1, are outstanding pigments which are notable in particular for better migration, light and solvent fastnesses, better heat stability and enhanced colouring power and also better dispersibility and capability to be brought into pigment form. The invention also relates to a process for preparing these epindolidione compounds and to their use a colorants for colouring polymer compositions or paper pulps, as colorants in electrophotographic toners and developers, as colorants in ink-jet inks, as colorants in the coatings industry, as colorants for textile printing or as a printing ink in the graphical industry, as colorants in cosmetics.

    摘要翻译： A'，R 2“和A”具有权利要求1中给出的含义的通式（I）的环亚二醇二醇化合物是突出的颜料，特别是对于更好的迁移，轻和耐溶剂性 ，更好的热稳定性和增强的着色力，并且还具有更好的分散性和使其成为颜料形式的能力。 本发明还涉及一种制备这些环丁二烯化合物的方法及其用于着色剂的着色剂，用于着色聚合物组合物或纸浆，作为电子照相色调剂和显色剂中的着色剂，作为喷墨油墨中的着色剂，作为涂料工业中的着色剂，如 用于纺织印花的着色剂或作为图形行业的印刷油墨，作为化妆品中的着色剂。

    Yellow pigmented food package
    8.
    发明授权
    Yellow pigmented food package 失效
    黄色色素食品包装

    公开(公告)号：US06475543B2

    公开(公告)日：2002-11-05

    申请号：US09872805

    申请日：2001-06-02

    申请人： Bansi Lal Kaul

    发明人： Bansi Lal Kaul

    IPC分类号： B65D85100

    CPC分类号： C08K5/0041 ,  C09B63/005

    摘要： Use of a pigment of the formula (I) wherein R is chloro or methyl as a colourant in plastics materials for food packaging.

    摘要翻译： 其中R是氯或甲基的式（I）的颜料在塑料材料中用于食品包装的着色剂。

    Dyeability or mass coloration of synthetic polyamide
    9.
    发明授权
    Dyeability or mass coloration of synthetic polyamide 失效
    合成聚酰胺的染色或大量着色

    公开(公告)号：US5932640A

    公开(公告)日：1999-08-03

    申请号：US882508

    申请日：1997-06-25

    申请人： Bansi Lal Kaul ,  Angelos Elie Vougioukas

    发明人： Bansi Lal Kaul ,  Angelos Elie Vougioukas

    IPC分类号： C08G69/48 ,  C08G73/06 ,  C08G73/18 ,  C08K5/16 ,  C08K5/3435 ,  C08L77/00 ,  D06P1/642 ,  D06P5/06 ,  C08K5/34

    CPC分类号： D01F6/60 ,  C08G69/48 ,  C08G73/0644 ,  C08G73/18 ,  C08K5/16 ,  C08K5/3435 ,  C08L77/00 ,  D01F1/10 ,  D06P1/6426 ,  D06P5/06

    摘要： 1. Synthetic polyamide comprising one or more of the following compounds:a) a compound having at least one sterically hindered amino group, �hereinafter referred to as compounds a)!; orb) a trimesinic acid trialkylamide, at least one alkyl group of which bears at least one free amino and/or alkylamino group �hereinafter referred to as compounds b)!; orc) a trialkylamino-substituted triazine, at least one alkyl group of which carries a free amino and/or alkylamino group �hereinafter referred to as compounds c)!; ord) a dyestuff that is free of sulphonic acid groups and contains at least one group that is reactive to a hydroxy and/or amino group �hereinafter referred to as compounds d)!; ore) a synthetic polyamide containing at least one group that is reactive with a hydroxy and/or amino group �hereinafter referred to as compounds e)!.

    摘要翻译： 1.包含一种或多种以下化合物的合成聚酰胺：a）具有至少一个位阻氨基的化合物，[以下称为化合物a）]; 或b）至少一个烷基含有至少一个游离氨基和/或烷基氨基的塔米尼酸三烷基酰胺[以下称为化合物b）]; 或c）三烷基氨基取代的三嗪，其至少一个带有游离氨基和/或烷基氨基的烷基（以下称为化合物c）]; 或d）不含磺酸基并且含有至少一个对羟基和/或氨基具有反应性的基团[以下称为化合物d]]的染料; 或e）含有至少一个与羟基和/或氨基反应的基团的合成聚酰胺[以下称为化合物e）]。