- 专利标题： CASPASE INHIBITOR PRODRUGS
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申请号： US12971649申请日： 2010-12-17
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公开(公告)号： US20110137037A1公开(公告)日： 2011-06-09
- 发明人: Steven Durrant , Jean-Damien Charrier , John Studley
- 申请人： Steven Durrant , Jean-Damien Charrier , John Studley
- 申请人地址： US MA Cambridge
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07D498/04
- IPC分类号： C07D498/04
摘要：
This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors.This invention also relates to the processes for preparing these prodrugs of caspase inhibitors.This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
公开/授权文献
- US08168798B2 Caspase inhibitor prodrugs 公开/授权日：2012-05-01
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