发明申请
- 专利标题： POLYMERIZED CYCLIC NITROXIDE RADICAL COMPOUND AND USE THEREOF
- 专利标题（中）： 聚合的环状硝酸盐化合物及其用途
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申请号： US12990575申请日： 2008-12-04
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公开(公告)号： US20110142787A1公开(公告)日： 2011-06-16
- 发明人: Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
- 申请人： Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
- 优先权： JP2008-120626 20080502; JP2008-178150 20080708
- 国际申请： PCT/JP2008/072467 WO 20081204
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C08G65/48 ; C12Q1/28 ; A61P9/10 ; A61P7/10 ; A61P25/00 ; A61P29/00 ; A61P9/12 ; A61P3/06 ; A61P3/04 ; A61P39/06
摘要：
A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.
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