发明申请
- 专利标题： PREPARATION OF OPIATE ANALGESICS BY REDUCTIVE ALKYLATION
- 专利标题（中）： 通过减少烷基化制备优质药物
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申请号： US13030652申请日： 2011-02-18
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公开(公告)号： US20110144341A1公开(公告)日： 2011-06-16
- 发明人: Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- 申请人： Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- 申请人地址： GB London
- 专利权人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- 当前专利权人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- 当前专利权人地址： GB London
- 优先权： GB0421687.5 20040930
- 主分类号： C07D489/08
- IPC分类号： C07D489/08 ; C07D489/02
摘要：
A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, C(CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process is a reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.
公开/授权文献
- US08318937B2 Preparation of opiate analgesics by reductive alkylation 公开/授权日：2012-11-27
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