发明申请
US20110171287A1 Use of Oligonucleotides with Modified Bases as Antiviral Agents
审中-公开
使用寡核苷酸与修饰的碱基作为抗病毒剂
- 专利标题： Use of Oligonucleotides with Modified Bases as Antiviral Agents
- 专利标题（中）： 使用寡核苷酸与修饰的碱基作为抗病毒剂
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申请号： US12741531申请日： 2008-11-05
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公开(公告)号： US20110171287A1公开(公告)日： 2011-07-14
- 发明人: Mart Saarma , Andres Merits , Mati Karelson
- 申请人： Mart Saarma , Andres Merits , Mati Karelson
- 申请人地址： EE Tallinn
- 专利权人： BALTIC TECHNOLOGY DEVELPMENT, LTD.
- 当前专利权人： BALTIC TECHNOLOGY DEVELPMENT, LTD.
- 当前专利权人地址： EE Tallinn
- 国际申请： PCT/FI2008/050633 WO 20081105
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/7115 ; C07H21/00 ; C12N9/96 ; C12Q1/70 ; C12N5/07 ; A61P31/12 ; A61P31/14 ; A61P31/20
摘要：
The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
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