发明申请
- 专利标题: UREA COMPOUND OR SALT THEREOF
- 专利标题(中): 尿素化合物或其盐
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申请号: US12377918申请日: 2007-08-22
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公开(公告)号: US20110172230A1公开(公告)日: 2011-07-14
- 发明人: Takahiro Ishii , Takashi Sugane , Akio Kakefuda , Tatsuhisa Takahashi , Tokatoshi Kanayama , Kentaro Sato , Ikumi Kuriwaki , Chika Kitada , Jotaro Suzuki
- 申请人: Takahiro Ishii , Takashi Sugane , Akio Kakefuda , Tatsuhisa Takahashi , Tokatoshi Kanayama , Kentaro Sato , Ikumi Kuriwaki , Chika Kitada , Jotaro Suzuki
- 优先权: JP2006-226072 20060823
- 国际申请: PCT/JP2007/066236 WO 20070822
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D401/12 ; A61K31/4545 ; C07D211/46 ; A61K31/445 ; C07D401/06 ; A61K31/454 ; A61K31/496 ; C07D403/06 ; C07D401/14 ; A61K31/497 ; C07D403/12 ; A61K31/501 ; A61K31/4725 ; A61K31/4709 ; C07D413/14 ; A61K31/506 ; A61K31/53 ; A61P13/00
摘要:
[Object] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly urinary frequency, urinary incontinence and/or overactive bladder.[Means for solution] It is confirmed that a urea compound chemical-structurally characterized by having a piperidine or piperazine ring or a salt thereof has an excellent FAAH-inhibitory activity, and thus the present invention is completed. The urea compound or its pharmaceutically acceptable salt of the present invention can increase the effective bladder capacity and ameliorate the state of urinary frequency, and is therefore useful as an agent for treating urinary frequency, urinary incontinence and/or overactive bladder.
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