发明申请
US20110172274A1 FLUORO-SUBSTITUTED 3,4-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDINE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY
审中-公开
具有CB1拮抗活性的氟取代的3,4-二基-4,5-二氢-1H-吡唑-1-羧酰胺衍生物
- 专利标题: FLUORO-SUBSTITUTED 3,4-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDINE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY
- 专利标题(中): 具有CB1拮抗活性的氟取代的3,4-二基-4,5-二氢-1H-吡唑-1-羧酰胺衍生物
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申请号: US12999494申请日: 2009-06-15
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公开(公告)号: US20110172274A1公开(公告)日: 2011-07-14
- 发明人: Josephus H.M. Lange , Bernard J. Vliet, Van
- 申请人: Josephus H.M. Lange , Bernard J. Vliet, Van
- 优先权: EP08158309.8 20080616
- 国际申请: PCT/EP2009/057323 WO 20090615
- 主分类号: A61K31/454
- IPC分类号: A61K31/454 ; C07D401/12 ; A61P3/04 ; A61P9/00 ; A61P25/30 ; A61P1/16 ; A61P31/00
摘要:
This invention concerns fluorinated 3,4-diaryl-4,5-dihydro-1H-pyrazole-1-carboxamidine derivatives as cannabinoid-CB1 receptor antagonists, methods for preparing these compounds, novel intermediates useful for the synthesis of said compounds, methods for the preparation of these intermediates, pharmaceutical compositions containing one or more of these dihydropyrazole derivatives as active ingredient, as well as the use of these pharmaceutical compositions for the treatment of obesity and obesity-related cardiovascular disorders, drug addiction, cognition deficits, liver fibrosis and inflammatory disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
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